We take testing to another level—because that's what it takes to own your mind. Our Process Our Formulas Sourcing Testing Trials Insights Nootropics needed pharmaceutical-grade testing. We delivered. Rigorous testing and comprehensive consumer trials come standard for pharmaceutical drugs, but not nootropics. We weren’t satisfied with existing scientific data around active ingredients, so when we founded Thesis, we started to collect our own. Today, we've conducted thousands of trials and collected 7.3 million data points from our customers — and counting. Our 5-part formulation process builds from all of this so you can trust that when you choose Thesis, you’re not guessing with nootropics. You’re choosing a cognitive conditioner that'll actually work. Guaranteed results or your money back. We’re confident in our products and their precise blend of ingredients because they’ve gotten real results for millions of customers. We offer a money-back guarantee that a Thesis product will work for you—and if an existing product we offer won’t, we’ll work with you to develop one that does. With Clarity, feel 54% more focused or get your money back. Shop Now With Motivation, feel 48% more focused or get your money back. Shop Now With Stress Reset, feel 63% less stressed or get your money back. Shop Now With Neuroprotection, feel 50% less forgetful or get your money back. Shop Now Previous slide Next slide Previous slide Previous slide Next slide Next slide Clinically researched. Precisely formulated. Thesis uses isolated, plant-derived compounds rather than blends or extractions. This allows us to control consistency and experiment to determine the most effective dose of each ingredient to get the best results possible. 4x Higher than other nootropics We eliminate variables by isolating actives by price ratio and standardizing dosages—at 4x the industry standard. Clinically researched. Precisely formulated. Thesis uses isolated, plant-derived compounds rather than blends or extractions. This allows us to control consistency and experiment to determine the most effective dose of each ingredient to get the best results possible. 4x Higher than other nootropics Thesis runs 10 trials per year on average. 4x Higher than other nootropics We eliminate variables by isolating actives by price ratio and standardizing dosages—at 4x the industry standard. Fig B. Clarity 4-ingredient formula Many nootropics make baseless claims. We conduct real-world testing. We conduct continuous beta testing and open-label trials to assess real-world effectiveness. Our studies are designed with the rigor and ethical standards typically reserved for pharmaceutical clinical trials. 30+ Beta Tests Thesis has run over 30 beta tests with real customers. 700+ Studies Thesis reads and analyzes 700+ studies when formulating. 7.3M Data Points 7.3 million data points collected across thousands of customer trials. An informed hypothesis Thesis’ science team and board of scientific advisors are constantly iterating based on our own data, new studies and cognitive research. Every process begins with a systematic review of literature that helps inform a hypothesis we set out to validate at scale. We then formulate based on these hypotheses. Blind trials. With formulas in hand, we conduct a series of two week long blind trials. Hundreds of participants receive our formulas and a questionnaire based on a set of scientific criteria designed to standardize the results. Analyze and iterate. At the end of a trial all data is analyzed to determine the most effective formulation and that formula is rolled at a larger scale, evaluated again and improved if necessary. Product development is a continuous process at Thesis, we’re always iterating, testing and improving. We’re devoted to continual improvement. Our process is driven by two questions: why and how. We’re constantly reevaluating every decision we’ve made, and asking new questions in search of better outcomes for those who love and trust Thesis. Here are the latest questions that drive what we do: 1 Which ingredient combinations most effectively support distraction-proof focus in a dopamine-saturated world? Modern life hijacks attention with constant pings, scrolls, and dopamine spikes. Clarity targets this head-on by combining Citicoline, Lion’s Mane, and 7,8-DHF to promote neuroplasticity, acetylcholine signaling, and dopamine regulation. This stack helps support distraction resistance, sustained attention, and the deep work required for modern cognitive demands. 2 How can we support our brains to thrive now and stay sharp for decades to come? Cognitive health isn’t just about a better workday. It’s about protecting what makes you you. From dopamine and Acetylcholine for daily drive and focus, to Sulforaphane, Spermidine, and mitochondrial activators for long-term resilience, our formulas are designed to support both high performance today and brain longevity tomorrow. 3 How does Stress Reset better support serum cortisol levels compared to previous formulations? Stress Reset combines Shoden® Ashwagandha, clinically shown to reduce cortisol by up to 67% and occasional anxiety by 59%, with Zembrin® and Salidrosides for sharper mood regulation and cognitive flexibility. This version supports serotonin, dopamine, and alpha wave activity, without sedation or crash. Here’s what we’re reading, if you’re curious, too: THE NEW YORK TIMES Generation Adderall THE NEW YORK TIMES Stop Letting Modern Distractions Steal Your Attention THE WALL STREET JOURNAL ‘Super Agers’ Review: Living the Good Life find your brain's best formULA Get Started
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